When using a medicated nasal spray, rinsing before using your medication helps to prepare the nose by cleaning and removing any debris. A cleaned-out nose can help make the medicine more effective. After nasal irrigation, wait 3-5 minutes for the nasal cavity to dry before using nasal spray.

Is it harmful to gag on saline nasal irrigation?
If you gag on saline solution or accidentally swallow saline solution during nasal irrigation, don’t